Present study was undertaken to evaluate anti-diabetic activity of Saptarangydi ghanavati in established experimental animal model. Eighteen adult Wister stain albino rats of either sex weighing between 180�±25g were selected and made diabetic by injecting Streptozotocin. The diabetic rats were divided into three groups, having 6 animals in each group. A separate group (normal control) containing six rats was kept to get normal values and for comparison. Saptarangydi ghanavati was suspended in water and administered to animals at the dose of 270 mg/kg for 20 consecutive days. Glibenclamide was used as standard anti-diabetic drug. Parameters like effect on body weight, weight of liver and kidney, blood sugar level, serum cholesterol, serum triglyceride, HDL cholesterol, S.G.P.T. and S.G.O.T. activity, alkaline phosphates activity and glycosylated hemoglobin, cytoarchitecture of pancreas, liver and kidney were studied. Treatment with Saptarangydi ghanavati moderately decreased blood sugar level at all time intervals in non-significant manner. Further it produced moderate protection of pancreas and marked protection of liver and kidney against the toxicant. This study shows Saptarangydi ghanavati is having moderate anti-diabetic activity besides it is having marked cytoprotectve activity.
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